Son of Henry Home, Lord Kames and Agatha Drummond. Married Janet Jardine (d. 1840) in 1782. He inherited the title and estate of Blair Drummond from his maternal uncle George Drummond of Blair Drummond (d. 1765).
In 1762-3 he was described by Boswell as "a good honest fellow [who] applies well to his business as a merchant" . 1
Boswell became acquainted with George Home through his visits to Home's father, Lord Kames, where, according to Boswell himself, he (Boswell) had been all giddiness. On January 1, 1763, however, George Home expressed how, when visiting Boswell in his Downing Street lodgings, he "was astonished to find [Boswell] settled on so prudent a plan". They met a few more times during Boswell's 1762-3 London stay.1