Daughter of John Douglas, 3rd Bart. of Kelhead, and Christian Cunningham. Married (1767) to Dr. William Butter of London.
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On his Grand Tour of Europe in 1764-1765, Boswell visited and befriended the famous philosophers Jean-Jacques Rosseau and François-Marie Arouet (Voltaire), and back in Edinburgh he was a personal friend of David Hume.